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management differential treatment blood product reactions algorithm anca antibody antineutrophil antinuclear arterial classification coagulation dic disease disseminated embolism erythematosus glomerulonephritis
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Vasculitis: • ... + 60% • Eosinophilic ... Jcortesizaguirr #ANA ... #diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Purpura Anti-GBM antibodies ... #differential #diagnosis ... #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... often causes arthritis ... LFT • ESR • ANA ... ) pattern: antibodies ... #rheumatology #
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
IgG4-Related Disease ... phase reactants, eosinophilia ... autoantibodies (antinuclear antibodies ... No necrosis, No vasculitis ... workup #treatment #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... progressive) EGPA (Eosinophilic ... Polyangiitis): • Eosinophilia ... often causes arthritis ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... thickening or effusion ... ) • Cutaneous vasculitis ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
vasculitis (AAV ... life-threatening diseases ... EGPA) • Auto-antibodies ... LVEF, pericardial effusion ... Goodpasture's cause
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... Antiphospholipid antibodies ... 19 - PNH - Vasculitis ... Venous #Arterial #pathophysiology ... #hematology #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... Lungs: • Pleural effusions ... #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
S Pathophysiology ... • Severe Liver Disease ... HIT: Heparin-PF4 antibodies ... #Coagulation #diagnosis ... #management #hematology
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