2378 results
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Microangiopathy - TMAs ... MAHAs are due to TMAs ... but (almost) all TMAs ... TMA is a triad of ... and secondary TMA
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Microangiopathy (TMA ... Complement-mediated TMA ... - Drug-induced TMA ... Metabolism-mediated TMA ... Microangiopathy #TMA
Thrombotic Microangiopathy (TMA) - Diagnosis and Management Algorithm

#Thrombotic #Microangiopathy #TMA #Diagnosis #Management #Algorithm #hematology
Microangiopathy (TMA ... Microangiopathy #TMA
Thrombotic Microangiopathy (TMA) - Diagnostic and Management Algorithm

#Thrombotic #Microangiopathy #TMA #Diagnosis #Management #Algorithm #workup
Microangiopathy (TMA ... Microangiopathy #TMA
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
microangiopathies (TMA ... Complement-mediated TMA ... (DITMA) - TMA
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Microangiopathy (TMA ... Algorithm Suspected TMA ... Microangiopathy #TMA
Wall Motion Abnormalities!

1. Hypokinesis = ↓ Squeeze
2. Akinesis = No Squeeze
3. Dyskinesis = Outward Bulging

Sam Ghali,
twitter.com/EM_RESUS #WMA ... Hypokinesis #PSAX #POCUS
Thromboelastogram Interpretation
Reaction Time (R Value):
 - Time till initiation of fibrin clot
 - Treatment: FFP, protamine
K
Maximum Amplitude (MA ... minutes after MA ... - Treatment: TXA
Tranexamic Acid: Mechanism of Action
 - TXA is an anti-fibrinolytic
 - TXA is a synthetic analog
Mechanism of Action - TXA ... anti-fibrinolytic - TXA ... acid lysine - TXA ... to plasmin - TXA ... pathophysiology #hematology #TXA
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
TTP from other TMA ... (vs. secondary TMA