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Pathologic Red Blood Cell (RBC) Morphologies and Associated Diseases

Acanthocyte (spur cell),  
Basophilic stippling, 
Bite cell,
Red Blood Cell (RBC ... Spherocyte, Teardrop ... cell, Other RBC ... Howell-Jolly bodies #RBC
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell (RBC ... Morphology Microcytic RBC ... sometimes) Macrocytic RBC ... Bite Cell RBC: G6PD ... S-beta thalassemia Teardrop
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Hemoglobinopathies • Teardrop ... coagulopathy (DIC) #RBC
Several artifacts can cause significant and potentially misleading alterations to measured RBC parameters: 
1. Old samples
alterations to measured RBC ... samples cause RBCs ... the tube causes RBCs ... a falsely low RBC ... #Dacrocytes, #Teardrops
Urine Microscopy and Casts - Image Atlas Key

- Squamous Epithelial Casts
- Transitional Epithelial Cells
- Renal Tubular
- Monomorphic RBCs ... - Dysmorphic RBCs ... Granular Casts - WBC ... Cast - RBC Cast
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
/ Normochromic RBCs ... TIBC, Hypochromic RBCs ... Decreased RBC ... Thalassemia • RBC ... Disorder • RBC
Urinalysis Interpretation (UA)

Bacteria, Leukocyte esterase, WBC, Nitrite, RBC, Epithelial 
cells, pH

#Diagnosis #Urinalysis #Interpretation #Analysis
Leukocyte esterase, WBC ... , Nitrite, RBC,
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
resemble a pear or teardrop ... Smear #Dacrocytes #Teardrop
Extension teardrop fracture - Small triangular avulsion of anteroinferior vertebral body, at insertion point of anterior
Extension teardrop ... spine #Ortho #Teardrop
The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes:

Conditions with Abnormal RBCs:
 •
with Abnormal RBCs ... : • Abnormal RBC ... Xerocytosis • RBC