33 results
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... activates lipolysis Signs ... /Symptoms: • GH ... deficiency: - Short ... expansion (e.g. carpal
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
GH excess prior ... overgrowth: • Carpal ... Tunnel Syndrome ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
Scapholunate Dissociation
The spacing between all carpal bones should be 1-2 mm, look for the "Terry Thomas"
spacing between all carpal ... "Terry Thomas" sign ... ("Terry Thomas sign ... #Dissociation #TerryThomas ... #Orthopedics #Sports
Rheumatoid Arthritis Summary
MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
PIP Involvement, Spares ... DIP, Carpal Tunnel ... , Sicca Syndrome ... #rheumatology #signs ... #symptoms
Ramsay Hunt Syndrome - Herpes Zoster Oticus 
Triad:
1. Ipsilateral facial paralysis 
2. Ear pain 
3. Vesicles
Ramsay Hunt Syndrome ... in the auditory canal ... • Stroke syndromes ... Oticus #Diagnosis #Symptoms ... #Signs
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
paresthesias (carpal ... decade → peripheral/acral ... • GH stimulates ... Beckwith Wiedemann syndrome ... Endocrinology #Treatment
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Hypothyroidism – symptoms ... and signs. ... Symptoms: Tiredness ... peripheries, Carpal ... timel syndrome,
Short Stature - Differential Diagnosis Algorithm
Normal Variant, Normal Puberty Onset (BA = CA)
 • Familial Short
Short Stature - ... 21 • Noonan Syndrome ... • Turner Syndrome ... Cushing's Disease • GH ... Panhypopituitarism Treatment
Risk Factors and Signs of Copper Deficiency
Risk Factors:
 • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Risk Factors and Signs ... Chronic diarrhoea, Short ... bowel syndrome, ... dental fixatives, Treatment ... #riskfactors #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... =>Prader-Willi Syndrome ... Signs/Symptoms ... fractures • Short ... #PraderWilli #Syndrome