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adultonset druginduced hematology sle stills syndrome activation causes coagulation comparison disseminated erythematosus intravascular macrophage mas sjogrens summary systemic table tafro
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
(DIL): • Epidemiology ... rash is rare in DIL ... for cutaneous DIL ... for cutaneous-DIL ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... of SLE versus DIL ... life-threatening • Treatment ... Evolution: Chronic disease ... #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... synovitis (40%) Treatment ... #AOSD #rheumatology ... #diagnosis #management ... #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Differential Diaqnoses ... MAS, Visceral, DIC ... #diagnosis #management ... #treatment #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Intravascular Coagulation (DIC ... Manifestations of DIC ... MAHA: TTP/HUS > DIC ... for bleeding #DIC ... #management #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
(DIL) • Epidemiology ... rash is rare in DIL ... #DIL #rheumatology ... #diagnosis #treatment ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE], AOSD ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Diagnosis ... • Nephrogenic DI ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
including systemic lupus ... with interleukin (IL ... Histopathological Diagnoses ... Hypoalbuminemia Treatment ... #management #rheumatology
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