28 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
#Hemolytic #Anemia ... #Algorithm #Differential ... #Causes #Workup ... #Hematology #Diagnosis ... GrepMed Recommended Text
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
AIHA • Anemia ... • Blood smear: Differential ... FOR a cause → Systematic ... #management #treatment ... #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Congenital Diseases ... deficiency • Fanconi’s anemia ... : • Systemic lupus ... Antibody-mediated hemolysis ... #Diagnosis #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Defects: Sickle cell anemia ... Laboratory Tests ... #Differential # ... Diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... value is low, tests ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Vasculitides, IBD, Celiac disease
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
younger pts) Differential ... • Diagnostic Test ... Donath-Landsteiner test ... #hemolytic #anemia ... #hematology #diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... with leukopenia, anemia ... Liver function tests ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes
== Primary Skin Lesions ==
Macules /
Liver Function Tests ... Cholestatic liver disease ... renal failure/uremia ... syndrome Psychiatric Disease ... #generalized #dermatology