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hepatology transaminitis algorithm enzymes adultonset chemistry cholestatic disease function hepatitis hepatocellular interpretation management patterns rheumatology rvalue stills tests treatment
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... more specific for hepatic ... Transaminitis #diagnosis ... #differential #
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... injury) • Ischemic ... ) • Non-hepatic ... Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
- Hemolysis, NASH ... #Injury #hepatology ... #LFTs #transaminitis ... #differential # ... diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... replaced by non-hepatic ... #chemistry #diagnosis ... #differential # ... #LFTs #RValue #
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Injury: • Hepatic ... function may be abnormal ... #hepatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
arthritis, Skin rash ... fraction < 20% Differential ... Diaqnoses: • ... Complications: MAS ... splenomegaly • Hepatic
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... aminotransferase; BMI, body mass ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
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