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causes algorithm oncology anemia management hemolytic skin thrombocytopenia neutropenia thrombocytosis workup clinical cutaneous disorders hemolysis joint lad lymphadenopathy pain platelets
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Diagnosis Platelet ... deficiency) • Infection ... Sepsis • Non-infectious ... (malignancy, rheumatologic ... #Platelets #hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Connective Tissue, Infections ... Lymphocytosis: Infection ... Lymphocytopenia: Infections ... • Neutropenia: Infections ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... TPO, TPO-RA • Infections ... : Chronic infections ... bacterial and viral infections ... #hematology
Isolated Neutropenia - Differential Diagnosis Algorithm Chronic (>3 months): • Extrinsic: Vitamins • Intrinsic: Congenital, Inflammatory Transient: •
Neutropenia - Differential ... Diagnosis Algorithm ... Inflammation: Infectious ... , Non-infectious ... #hematology
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... Diagnosis Algorithm ... malignancies • Infection ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Lymphadenopathy - Differential ... Diagnosis Algorithm ... Inflammatory / Infectious ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Hemolytic Anemia - Differential ... Diagnosis Inherited ... Internal - Infectious ... #Diagnosis #Causes ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Diagnosis Algorithm ... Myelofibrosis Infectious ... #Diagnosis #Algorithm ... #Causes #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... Pseudotumor - Infectious ... History of Bleeding, Infection ... #Diagnosis #Algorithm ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... Extravascular #Causes #differential ... #diagnosis #hematology
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