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differential rheumatology pathophysiology autoimmune biphasic cns dermatology dermatomyositis encephalitis erythematosus extraarticular heatstroke infections leptospirosis lupus meningitis myopathy myositis neurology oncology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
Heat Illnesses and ... Rash: • Small ... → Syncope • Signs ... /Symptoms: - Lightheadedness ... #diagnosis #causes
Biphasic Illness of Leptospirosis Some patients do not progress to severe disease. Others, rapidly develop severe disease
Biphasic Illness ... brief interval symptom ... maculopapular rash ... Biphasic #Phases #Diagnosis ... #Illness #Signs
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
processes occur in the skin ... -> Heliotrope Rash ... Polymyositis #PM #Diagnosis ... Pathophysiology #Signs ... #Symptoms #Vasculitis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Sjögrens (15%) Skin ... Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... erythematosus #signs ... #symptoms #diagnosis
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
blood vessels (vasculitis ... (Xerostomia) Heart ... inflammation tends to cause ... pathophysiology #signs ... #symptoms #diagnosis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
- Rash: multiple ... Episcleritis Signs ... Causes: - Idiopathic ... influenza-like illness ... Leukocytoclastic vasculitis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... , mucositis • Rash ... • Progressive symptoms ... tract, and often causes
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
Coltivirus Symptoms ... Maculopapular rash ... Acute meningeal signs ... second phase of the illness ... • Uveitis • Rash
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Anti-MDA5 (RP-ILD ... ) • Anti-Mi2 (skin ... : • Gottron rash ... elevated < PM and DM ... the spine) or head
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