10 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... gangrenosum • IBD ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... of Systemic Lupus ... Sjögrens (15%) Skin ... , Vasculitis, Purpura ... #erythematosus #
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lupus erythematosus ... Clinical Presentation ... (Petechial or purpuric ... rash) • Heart, ... lupus erythematosus
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Suspect: Clinical ... 3rd Decade Skin ... lupus erythematosus ... #Lupus #Erythematosus
Acute Purpura Fulminans Skin Rash on Physical Exam 
60 year old male ITP s/p splenectomy 
1d
Skin Rash on Physical ... Exam 60 year old ... shock, multiorgan system ... #Rash #clinical ... #photo
DRESS Syndrome vs SJS/TEN
DRESS
 • Latency: 2-8 weeks
 • Rash: Morbilliform
 • Mucosal involvement: 50% have
DRESS Syndrome vs ... : 2-8 weeks • Rash ... : Painful erythematous ... macules with purpuric ... TEN #comparison #table
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
inflammation Others: • Lupus ... : erythematous nodules ... mucositis - Rash ... • Cogan Syndrome ... lupus erythematosus
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... - Skin ulcers ... : • Clinical triad ... reticularis & skin ... lupus erythematosus
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... NPSLE rare, Malar rash ... months to years) Systemic ... Lupus Erythematosus ... sle #comparison #table
Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE)

49M +burning rash groins/buttocks (pic in next thread) x 1d.
well-demarcated, erythematous ... known as baboon syndrome ... , blisters, or purpura ... Washington University ID ... #clinical #photo