11 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... Crohn's disease Palpable ... gangrenosum • IBD ... Antiphospholipid-antibody syndrome
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Petechiae, Palpable ... Maculopapular rash ... • Petechiae • Palpable ... • Goodpasture syndrome ... #dermatology #rash
Palpable Purpura seen in Henoch Schonlein Purpura (HSP, IgA Vasculitis)

55 year old male on tuberculosis treatment
Palpable Purpura ... Vasculitis) 55 year old ... rash. ... Vasculitis #clinical #photo ... #dermatology #skin
Henoch Schonlein Leg Rash - Palpable Purpura
Purpura: Low Platelets or Vasculitis?
45 years old, seen in our
- Palpable Purpura ... 45 years old, seen ... Palpable purpura ... later confirmed by skin ... #photo #dermatology
DRESS Syndrome vs SJS/TEN
DRESS
 • Latency: 2-8 weeks
 • Rash: Morbilliform
 • Mucosal involvement: 50% have
DRESS Syndrome vs ... : 2-8 weeks • Rash ... involvement: 50% have mild ... : Painful erythematous ... macules with purpuric
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... Systemic lupus erythematosus ... easy bruising to purpura ... (Petechial or purpuric ... rash) • Heart,
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
evidence of (fatigue, rash ... 3rd Decade Skin ... CNS • Headache, mild ... Seizures • Strokes Skin ... Chronic B-cell activation
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
: erythematous nodules ... mucositis - Rash ... systemic lupus erythematosus ... scleritis • Palpable ... -> causing palpable
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
: Erythematous nodules ... , mucositis • Rash ... ) • Palpable purpura ... vasculitis • Behcet syndrome ... vasculitis • Cogan syndrome
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
: • Nephrotic syndrome ... Carpal tunnel syndrome ... • Periorbital purpura ... Inflammation → Macrophage activation ... arrhythmia • Palpable