36 results
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... #Osteoporosis #pathophysiology ... #signs #symptoms ... #diagnosis
Spondylolysis & Spondylolisthesis: Pathogenesis and Clinical Findings

Pars interarticularis stress fracture (spondylolysis) - most frequently in the
tenderness • Positive one-legged ... XR — scotty dog sign ... Spondylolisthesis #MSK ... #diagnosis #pathophysiology ... #signs #symptoms
Diagram of different types of bone tumors that can occur around the knee on XRay -
different types of bone ... blade of grass sign ... ) • Enostosis/bone ... docskalski #Knee #Bone ... #Tumors #Diagnosis
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Symptoms: Commonly no signs ... easily/weakness, Bone ... /joint pain Psychiatric ... Hyperparathyroidism #diagnosis ... Secondary #Tertiary #pathophysiology
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Clonus, Babinski’s sign ... • Lhermitte’s sign ... pupillary defect SIGNS ... Signs and symptoms ... criteria for MS
McDonald Criteria for Diagnosis of Multiple Sclerosis
 • 2 or more attacks, 2 or more lesions
for Diagnosis of ... more lesions - None ... progression from onset - One ... year of disease ... #Sclerosis #MS
Diagram of different types of bone tumors that can occur around the knee on XRay
Age <
different types of bone ... • Aneurysmal bone ... blade of grass sign ... #Differential #Diagnosis ... Radiology #XRay #MSK
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... in macrophages Diagnosis ... Osteonecrosis, bone ... #Diagnosis #Signs
Whipple Disease (Tropheryma whipplei) - Diagnosis and Management 

Caused by: Tropheryma whipplei

Symptoms and Signs:
1. Migratory poly/oligoarthralgia
Whipple Disease ... Symptoms and Signs ... Criteria - Either ... one of: • Oculomasticatory ... specimen OR • One
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Erythematosus #SLE #MSK ... Complications #pathophysiology ... #signs #symptoms ... #diagnosis