65 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
heliotrope rash, Shaw sign ... , holster sign, ... anti-synthetase syndrome ... /full triad at diagnosis ... #diagnosis #rheumatology
Sjogren Syndrome - Signs, Symptoms and Diagnosis

#Sjogren #Syndrome #Signs #Symptoms #Diagnosis #rheumatology
Sjogren Syndrome ... - Signs, Symptoms ... and Diagnosis ... #Signs #Symptoms ... #Diagnosis #rheumatology
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Anti-Synthetase Syndrome ... Inclusion Body Myositis ... MSAs #clinical #diagnosis ... #rheumatology #
Ramsay Hunt Syndrome - Herpes Zoster Oticus 
Triad:
1. Ipsilateral facial paralysis 
2. Ear pain 
3. Vesicles
Ramsay Hunt Syndrome ... neuropathy • Myelitis ... • Stroke syndromes ... HerpesZoster #Oticus #Diagnosis ... #Symptoms #Signs
Systemic Sclerosis (Scleroderma)
Limited - CREST:
 • Calcinosis
 • Raynaud phenomenon
 • Esophageal dysmotility
 • Sclerodactyly
 •
involve DIP • Myositis ... #Scleroderma #diagnosis ... #signs #symptoms ... #rheumatology
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
Other brainstem syndromes ... • Transverse myelitis ... positive NMO only): Myositis ... Manifestations #diagnosis ... neurology #symptoms #signs
Standardized Physical Abuse Guideline
<6 months of age
 • Social work consult
 • Skeletal survey
 • Head
age • Social work ... AST or ALT> 80, signs ... Abuse #Guidelines #Workup ... #Peds #Pediatrics ... #Diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... • Acute stroke syndromes ... Lack of UMN/LMN signs ... dystrophies Work ... #Differential #Diagnosis
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
skin thickening Signs ... acro-osteolysis, myositis ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Antiphospholipid Antibody Syndrome ... LAC) • Sjogren Syndrome ... Peptide (CCP) • Myositis ... #diagnosis #associations