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algorithm causes intravascular microangiopathy nonpalpable petechiae petechial rash thrombotic anemia arterial coagulation dic disseminated embolism extravascular hemolysis hemolytic hemolyticuremicsyndrome management
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... TTP/HUS indicates ... purpura/hemolytic ... , Hematology 2012 ... #Evaluation
Thrombotic Microangiopathy - TTP VS HUS Big picture points : Often hard to differentiate the two entities,
VS HUS Big picture ... Often hard to differentiate ... #purpura #TTP # ... #Comparison #Diagnosis ... #Table #Hematology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Petechial/Purpuric ... require emergent evaluation ... coagulopathy (DIC), or TTP ... purpura. ... #Diagnosis #Dermatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... OF NON-PALPABLE PURPURA ... Acute Infectious Purpura ... Diagnosis #hematology ... #nonpalpable #dermatology
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis Table ... • Thrombotic Thrombocytopenic ... Purpura (TTP) ... Microangiopathy #TMA #hematology ... diagnosis #HUS
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Fever • Toxic appearance ... Henoch Schonlein Purpura ... Non-Palpable Rash: - Purpura ... deficiency Work ... #Causes #dermatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... /TTP/DITMA) - ... #Coagulation #diagnosis ... treatment #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... uremic syndrome (HUS ... Extravascular #Causes #differential ... #diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
Evaluation for ... Thrombotic Thrombocytopenic ... Purpura Activity ... WBC count and differential ... #Workup #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperviscosity, TTP ... Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia ... other causes of purpura ... pathophysiology #hematology
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