16 results
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
Transaminases / Transaminitis ... Trauma: Shock liver ... • Autoimmune hepatitis ... images/10587 #Transaminitis ... Transaminases #hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Chronic Viral Hepatitis ... • Acute Viral Hepatitis ... (Drug-induced liver ... Diagnosis #hepatology #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... - Acute Viral Hepatitis ... , Toxic Hepatitis ... #Patterns #Liver ... hepatology #LFTs #transaminitis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... • Infections: Hepatitis ... hepatology #algorithm #Transaminitis ... #LFTs #hepatitis
Ascites - Differential Diagnosis
Chronic liver disease (cirrhosis or chronic hepatitis) - 80%
Underlying malignancy - 10%
Congestive heart
Ascites - Differential ... Diagnosis Chronic liver ... cirrhosis or chronic hepatitis ... Chylous <1% #Ascites
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
Causes of Ascites ... Liver disease ... - Alcoholic hepatitis ... - Acute fatty liver ... - Bile ascites
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Check Acute viral hepatitis ... Check Acute viral hepatitis ... Chronic viral hepatitis ... differential #Hepatology #transaminitis
Approach to the Hospitalized Patient with Cirrhosis
1) Recognize and Manage Decompensation
 • Ascites
 • Variceal Bleeding
Decompensation • Ascites ... Scenarios • Alcoholic Hepatitis ... Portosystemic Shunt • Liver
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... Alcohol-related liver ... disorder (e.g. ascites ... ), Chronic hepatitis ... • Autoimmune hepatitis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... malaise) → Acute liver ... develops (DIC, ascites ... Diagnosis: Viral Hepatitis