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diagnosis hepatology differential algorithm injury management abnormal acute calling causes chemistry chronic classification consultation dili elevated failure function giconsult hepatitis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... • NAFLD • Cirrhosis ... 1000): • DILI (Drug-induced ... Function #Tests #LFTs ... Diagnosis #hepatology #transaminitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) ... those with CLD (± cirrhosis ... Hepatitis (AAH) Drug-Induced ... #Failure #Cirrhosis ... #Hepatology #gastroenterology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Algorithm for Transaminitis ... 15X ULN - Drugs ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... #Patterns #Liver ... Injury #hepatology #LFTs ... #transaminitis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... EmoryGastroHep #DILI #Drug ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... Gl History - Cirrhosis ... - Vitals - LFTs ... Referral #Hepatology #Gastroenterology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... valproate, azoles), Drugs ... hepatology #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Failure (ALF): ... hepatitis: < 1 • Cirrhosis ... differential #Hepatology #transaminitis ... #LFTs #RValue #
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Viral • Drugs ... • Viral • Drugs ... Infiltrative • Cirrhosis ... • Others #LFTs
Portal Hypertension Classification by site of vascular obstruction 1) Post-hepatic Post-sinusoidal: Budd-Chiari syndrome 2) Intrahepatic Post-sinusoidal: Veno-occlusive disease 3)
3) Sinusoidal: Cirrhosis ... , Polycystic liver ... hepatic fibrosis, Drugs ... or secondary to cirrhosis ... Classification #gastroenterology
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