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diagnosis management hematology differential algorithm causes dermatology rheumatology signs cancer cardiology generalized mds pruritus secondary summary symptoms abnormal acidosis activation
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Syndrome (MD) - ... cytopenias (usually anemia ... #Syndrome #MDS ... #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Aplastic Anemia ... factor (GCSF) treatments ... marrow studies Treatment ... treatment (examples ... #hematology #oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Diagnosis Algorithm - Systemic ... Liver Function Tests ... renal failure/uremia ... Throbocythemia • Myelodisplastic ... syndrome Psychiatric
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... Liver Function Tests ... Liver Function Tests
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... • Hypocellular myelodysplastic ... syndrome (MDS) ... Treatment: ... #oncology #hematology
Dyspnea - Considerations with Malignancy Directly Malignancy Related: - Lymphangitic spread to lung - Malignant pleural effusion
metastases Treatment ... - Conduction system ... - Cytopenias (anemia ... Changes in Pre-Test ... differential #diagnosis #oncology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Initial screening test ... block • Sjogren syndrome ... polymyositis overlap syndrome ... severe disease Treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... with leukopenia, anemia ... Liver function tests ... Treatment: • Corticosteroids
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
clubbing Clarkson/Systemic ... neuropathy) • Systemic ... lymphoma Multi-System ... (-) hemolytic anemia ... Differential #Diagnosis #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... adults in the west ... • Neutropenia, anemia ... microglobulin Treatment ... diagnosis #workup #oncology
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