38 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
weakness, less systemic ... anti-synthetase syndrome ... - Classic triad ... at diagnosis). ... #diagnosis #rheumatology
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... Anti-Synthetase Syndrome ... MSAs #clinical #diagnosis ... #rheumatology # ... table
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
LAC) • Sjogren Syndrome ... Peptide (CCP) • Myositis ... • Scleroderma (Systemic ... #diagnosis #associations ... #table
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Systemic Sclerosis ... acro-osteolysis, myositis ... overlap • Vascular ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features of Systemic ... Demyelinating syndromes ... Glomerulonephritis Myositis ... signs #symptoms #diagnosis ... #rheumatology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... • Acute stroke syndromes ... central nervous system ... Peripheral Nervous System ... #Differential #Diagnosis
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
SSc: systemic sclerosis ... PSS: Sjogren syndrome ... LungDisease #CTILD #Diagnosis ... Differential #Comparison #Table ... #Pulmonary #Rheumatology
Causes of Palpitations
 • ARRHYTHMiA 
 • SINUS ARRYTHMIA 
 • ATRIAL FIBRILLATION 
 • ATRIAL
ARRYTHMIA • ATRIAL ... PARKINSON WHITE SYNDROME ... • ACQUIRED VALVULAR ... DRUG WITHDRAWAL SYSTEMIC ... #Differential #Diagnosis
Nail Findings & Associated Conditions
Change in color, texture, or shape can be harmless, but may suggest
an underlying systemic ... • Yellow Nail Syndrome ... #differential #diagnosis ... #dermatology #nails ... #table #lines
Nail Findings & Associated Conditions
Change in color, texture, or shape can be harmless, but may suggest
an underlying systemic ... • Yellow Nail Syndrome ... #differential #diagnosis ... #dermatology #nails ... #table #lines