15 results
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... anti-synthetase syndrome ... after 2 years of treatment ... #rheumatology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... Lack of UMN/LMN signs ... proximal weakness Myopathy ... • Autoimmune: ... #Differential #Diagnosis
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
features of another autoimmune ... antisynthetase syndrome ... infrequent extra-muscular ... Myopathies #IIMs #diagnosis ... #rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Vascular Sludging ... ) Meltzer's Triad ... : • Clinical triad ... Labs/Diagnosis: ... classification #rheumatology
Rheumatoid Arthritis - Signs and Symptoms
 • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans
 • Pulmonary:
Rheumatoid Arthritis - Signs ... Thrombocytosis, Felty's syndrome ... Arthritis #RA #Signs ... #Symptoms #diagnosis ... #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
and diplopia) • Vascular ... ) Differential Diagnosis ... Arthritis, AS Treatment ... #signs #symptoms ... #rheumatology #
Causes of Neutropenia - Differential Diagnosis
Neonate:
 - Infection - by far the most common cause
 -
- Differential Diagnosis ... hypertension and/or drug treatment ... neutropenia, Kostmann syndrome ... Chediak-Higashi syndrome ... #causes #hematology
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
- Differential Diagnosis ... • Symptoms and signs ... Vascular/Blockage ... MCTD, Sjogren syndrome ... differential #algorithm
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Diagnosis: • Dry ... demyelinating disease, myelopathy ... Adenocarcinoma Treatment ... #Rheumatology #
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
regurgitation • Autoimmune ... Libman Sacks) • Atrial ... Cholesterol emboli syndrome ... insult due to vascular ... hematuria, + RF Treatment