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diagnosis peds algorithm bilirubinemia hyperbilirubinemia inherited aflp biliary bilirubin childhood cholangitis cirrhosis fatty forms gastroenterology hematology immunization liver management mds
Approach to Neonatal Jaundice Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
Approach to Neonatal Jaundice ... Causes of pathologic ... Diagnosis #Peds #Pediatrics ... #Algorithm #Differential ... #Workup #bilirubinemia
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... Cholangitis #Jaundice ... #Differential # ... Diagnosis #Algorithm #Causes ... #Hepatology #bilirubinemia
Childhood Immunization Schedule: Why we immunize • Diphtheria Toxin -> URT inflammation causes pseudomembrane with hardened
URT inflammation causes ... organ ischemia -> Congenital ... , jaundice and RUQ ... Immunization #peds #pediatrics ... #pathophysiology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... (DIC, ascites, jaundice ... infiltration) Differential ... Liver #Pregnancy #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... hyperpigmentation • Jaundice ... bile ducts Differential ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
breastfeeding jaundice ... malaise, are common Crigler-Najjar ... and stress may cause ... Hyperbilirubinemia #Inherited #Congenital ... #bilirubin #hepatology
Inherited forms of Hyperbilirubinemia Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
Unconjugated Crigler-Najjar ... Hyperbilirubinemia #pathophysiology ... #congenital #hepatology ... #pediatrics #peds
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... formed or don’t work ... cotrimoxazol • Congenital ... Workup: • Complete ... blood count with differential
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