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diagnosis algorithm lfts liver causes cirrhosis congenital hematology inherited jaundice pbc pediatrics primary abscess apml bandemia bilirubin bilirubinemia cbc children
Isolated Hyperbilirubinemia - Differential Diagnosis Algorithm Direct Hyperbilirubinemia: Dubin-Johnson Syndrome, Rotor Syndrome Indirect Hyperbilirubinemia: - Trauma, Hematoma,
- Differential ... Gilbert's Syndrome, Crigler-Najjar ... Reticulocyte Count Abnormal ... #Isolated #Differential ... Diagnosis #Algorithm #hepatology
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Jaundice - Differential ... - Unconjugated Hyperbilirubinemia ... on Ultrasound Biliary ... Gallstones • Biliary ... Algorithm #Causes #Hepatology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... Smoking, Microbial triggers ... #PBC #Primary #Biliary ... #hepatology
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Unconjugated hyperbilirubinemia ... posthepatitis hyperbilirubinemia ... Gilbert syndrome, Crigler-Najjar ... reactions) Conjugated hyperbilirubinemia ... #unconjugated #differential
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Tests - Differential ... - CBD stone, Biliary ... LFTs #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Non-hemolytic Disorders of Hyperbilirubinemia ... common hereditary hyperbilirubinemia ... of about 30% of normal ... malaise, are common Crigler-Najjar ... Congenital #bilirubin #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Liver Enzymes - Differential ... disease US — Normal ... Duct Stone • Biliary ... Others #LFTs #Hepatology ... #LiverEnzymes #Differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... No extrahepatic biliary ... bile ducts Differential ... diagnosis #workup #hepatology
Inherited forms of Hyperbilirubinemia Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
Inherited forms of Hyperbilirubinemia ... Unconjugated Crigler-Najjar ... #pathophysiology ... #congenital #hepatology ... #pediatrics #peds
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Tests (LFTs) - Normal ... (GGT) - Liver, biliary ... Conjugated/DBili) - Biliary ... conjugation (Gillbert, Crigler-Najjar ... Interpretation #diagnosis #hepatology
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