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diagnosis lfts liver biliary pbc primary abnormal algorithm apml causes chemistry cholangitis complications congenital differentiation elevated forms function hematology hyperbilirubinemia
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... • NAFLD • Cirrhosis ... #Tests #LFTs #Differential ... #Diagnosis #hepatology ... #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Algorithm for Transaminitis ... Congenital, Others, Cirrhosis ... Elevated #Abnormal #Transaminitis ... Algorithm #diagnosis #hepatology
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary Cirrhosis ... - Pathophysiology ... Smoking, Microbial triggers ... Primary #Biliary #Cirrhosis ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
CMV), Alcoholic cirrhosis ... Liver #Injury #hepatology ... #LFTs #transaminitis ... #differential #
Etiology and Complications of Cirrhosis #Causes #Complications #Cirrhosis #Differential #Pathophysiology #Hepatology
Complications of Cirrhosis ... Complications #Cirrhosis ... #Differential # ... Pathophysiology ... #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary Cirrhosis ... 65 years PBC Pathophysiology ... cholestasis → Cirrhosis ... bile ducts Differential ... diagnosis #workup #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
hepatitis: < 1 • Cirrhosis ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... initiation • Differential ... diagnosis #management #hematology
Inherited forms of Hyperbilirubinemia Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
Unconjugated Crigler-Najjar ... Hyperbilirubinemia #pathophysiology ... #congenital #hepatology ... #pediatrics #peds
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