8 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome in APML ... the study) • Triggers ... ATRA treatment Pathophysiology ... PE, DAH, CHF, Anaphylaxis ... #diagnosis #management
Intraoperative Anaphylaxis - Guidelines for Crises in Anaesthesia
• Unexplained hypotension
• Unexplained bronchospasm (wheeze may be absent
Intraoperative Anaphylaxis ... of more of the signs ... re-administration of possible trigger ... #Anaphylaxis ... Checklist #Diagnosis #Management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... hyperviscosity syndrome • Triggers ... WBC >100k, + lab signs ... into serum • Triggers ... #diagnosis #management
Intraoperative Tachycardia - Guidelines for Crises in Anaesthesia
Tachycardia in theatre is often due to inadequate depth
not be treated as ... reservoir bag and APL ... • Also consider ... amniotic (→ 3-5); anaphylaxis ... Checklist #Diagnosis #Management
Hypotension - Guidelines for Crises in Anaesthesia

Hypotension is commonly due to unnecessarily deep anaesthesia, the autonomic
reservoir bag and APL ... rhythm, treat as ... • Also consider ... ischaemia → 3-12 o Anaphylaxis ... Checklist #Diagnosis #Management
Cardiac Arrest - Guidelines for Crises in Anaesthesia

The probable cause is one or more of: something
As soon as ... reservoir bag and APL ... 10) Acidosis Anaphylaxis ... Anesthesiology #Anesthesia ... Checklist #Diagnosis #Management
Cryptogenic Organizing Pneumonia - Illness Script

PATHOPHYSIOLOGY: Unknown trigger, reversible inflammatory/fibroproliferative process. Polypoid fibroblastic aggregates that plug
Illness Script PATHOPHYSIOLOGY ... : Unknown trigger ... Males=Females SIGNS ... usually misdiagnosed as ... Pneumonia #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... • In all patients ... Presentation • Common Signs ... Pathophysiology ... Approach • Initial management