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diagnosis hematology syndrome alkaline alp amyotrophic apml causes cop cryptogenic differential differentiation encephalopathy fungal hemeonc hemophagocytic hepatology hlh hyophosphatasia infections
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... Anaphylaxis, Acute Renal ... APML #diagnosis #management
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
adult population: also ... Malnutrition • Wilson's disease ... collection with EDTA Pathophysiology ... mineralization Symptoms ... respiratory failure • Neurologic
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... : • Triad of symptoms ... urine • Other symptoms ... of underlying disease ... Differential #Diagnosis #Management
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... Presentation: - Disease ... fasciculations Common Symptoms ... Lateral #Sclerosis #neurology ... #diagnosis #management
Cryptogenic Organizing Pneumonia - Illness Script PATHOPHYSIOLOGY: Unknown trigger, reversible inflammatory/fibroproliferative process. Polypoid fibroblastic aggregates that plug
Illness Script PATHOPHYSIOLOGY ... : Unknown trigger ... usually misdiagnosed as ... steroids for severe disease ... Pneumonia #diagnosis #management
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Shock, Autoimmune disease ... Etiology: • Pathophysiology ... Neurological symptoms ... Syndrome #diagnosis #management ... #neurology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
extrapulmonary disease ... or meningitic disease ... by culture or serology ... Aspergillosis Pathophysiology ... Fungal #Diagnosis #Management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... • In all patients ... ▪ Autoimmune diseases ... Common Signs and Symptoms ... Pathophysiology
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