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Diagnosis and Management of Gastroesophageal Reflux Disease (GERD)

Definition
Presentation
Medical Management
Extraesophageal Symptoms
Long-Term PPI Issues
Diagnosis Algorithm
Refractory GERD
Surgical and Endoscopic
Diagnosis and Management ... Gastroesophageal Reflux ... Disease (GERD) ... Extraesophageal Symptoms ... Gastroesophageal #Reflux
Gastroesophageal Reflux Disease (GERD) - Summary

GERD: Diagnosis
• Heartburn (substernal burning sensation) and acid regurgitation
• Chest pain
Extraesophageal
Gastroesophageal Reflux ... : Diagnosis • Heartburn ... reduction • Avoid “trigger ... #Disease #diagnosis ... #management #Gastroenterology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... hyperviscosity syndrome • Triggers ... into serum • Triggers ... Syndrome #TLS #diagnosis ... #management #hematology
GERD and Recommended Lifestyle Modifications
 • Avoid fatty meals
 • Avoid carbonated beverages
 • Avoid citrus,
GERD and Recommended ... citrus, if it triggers ... symptoms • Eat ... #reflux #acid # ... Modifications #management
Esophageal Necrosis
Etiology:
 - Ischemia and Gastric Outlet Obstruction with GERD may be inciting events
 - Associated
Obstruction with GERD ... injury (by acid reflux ... promote esophageal reflux ... melena - Other GI symptoms ... #management #gastroenterology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
the study) • Triggers ... ATRA treatment Pathophysiology ... opacities • Diagnosis ... : >3 symptoms, or ... #management #hematology
Cryptogenic Organizing Pneumonia - Illness Script

PATHOPHYSIOLOGY: Unknown trigger, reversible inflammatory/fibroproliferative process. Polypoid fibroblastic aggregates that plug
Illness Script PATHOPHYSIOLOGY ... : Unknown trigger ... Females SIGNS/SYMPTOMS ... misdiagnosed as CAP • Symptoms ... #management #pulmonary
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... Increased Jaw Jerk reflex ... fasciculations Common Symptoms ... Other possible diagnosis ... #management
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Common Signs and Symptoms ... Pathophysiology ... Approach • Initial management ... #Management #Hematology