30 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Increased red cell ... hyperplasia of bone ... Increased red cell ... Hemolysis #Hemolytic #Anemia ... #Hematology #Diagnosis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... Warm AIHA • Bone ... lymphoma • Marginal zone ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... bleeding, infections, bone ... - Blood and Bone ... • Headaches, bone ... neutropenia) • Bone
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hypercellular bone ... • Bone Marrow ... in the bone marrow ... blood smear • Bone ... #hematology #oncology
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Mean corpuscular (cell ... Red cell distribution ... Low in bone marrow ... #Workup #Hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... cytopenias (usually anemia ... • Bone marrow ... Allogeneic stem cell ... Management #treatment #hematology
Aplastic Anemia - Illness Script
Signs and symptoms:
 • Recurrent infections from neutropenia
 • Mucosal bleeding from
Diagnosis: • Pancytopenia ... with hypocellular bone ... Consider stem cell ... #diagnosis #management ... #treatment #hematology
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
and laboratory diagnosis ... a morphologic one ... non-specific red cell ... polychromatophilic cells ... #Hematology #Pathology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
Hypoproliferative (i.e. bone ... Hypogonadism • Bone ... Hyperproliferative (i.e. bone ... defects (e.g. sickle cell ... #diagnosis #calculation
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
40 ml/min A - Anemia ... more: • Clonal bone ... marrow plasma cell ... , B and T cell lymphoproliferative ... #hematology #oncology