132 results
Primary and Secondary Causes of Osteoporosis

Primary osteoporosis 
 - idiopathic juvenile osteoporosis 
 -  postmenopausal
and Secondary Causes ... Cushing syndrome ... intolerance Bone ... plasmacytoma) - diffuse bone ... Differential #Endocrine #Diagnosis
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... Pathogenesis and clinical ... Signs/Symptoms ... Infertility • Decr Bone ... mineral density and osteoporosis
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings

 • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Glucocorticoid-Induced Osteoporosis ... Pathogenesis and Clinical ... -> Reduced Bone ... pathophysiology #signs #symptoms ... #diagnosis
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
in macrophages Diagnosis ... in GBA1 gene Clinical ... Osteonecrosis, bone ... infarcts, osteoporosis ... #Signs #Symptoms
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Myopathy (Also caused ... Normal CK • Osteoporosis ... pathophysiology #signs #symptoms ... #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... and Management ... old, ~10,000 new cases ... • Bone marrow ... Myelodysplastic #Syndrome
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Fat Embolism Syndrome ... Trauma to the long bone ... accounts for —9096 of cases ... FES is a clinical ... #Symptoms
Subtrochanteric Femur Fracture: Pathogenesis and clinical findings
 • Subtrochanteric region spans 5 cm distally from the
Pathogenesis and clinical ... young people) • Osteoporosis ... damage weakens the bone ... #orthopedics #diagnosis ... #differential #causes
Priapism 

Secondary Causes:
Medications- intracavernosal injections, anticoagulants, PDE5 inhibitors, alpha blockers, methylphenidate, cocaine
Any hyperviscosity syndrome (SCD, leukemia,
Secondary Causes ... hyperviscosity syndrome ... Some other random ones ... #Priapism #Diagnosis ... #Management #Urology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... : • A clinical ... diagnosis • Rule ... out other causes ... #management #Dermatology