14 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
) - Differential ... (>1000): • DILI ... (Drug-induced liver ... injury) • Ischemic ... Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Stepwise Diagnosis ... Algorithm DILI ... #Diagnosis #Algorithm ... #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Function Test (LFTs ... abnormality vs bone Bili ... Hospital of Baltimore IM ... Transaminitis #diagnosis ... #hepatology
Differential Diagnosis of Hypoglycemia
Evaluation of Hypoglycemia
Patients with known diabetes who are not systemically ill and can
Differential Diagnosis ... consider: - BMP - LFT ... #EM #IM #Hypoglycemia ... Algorithm #Drugs ... #Hypoglycemic #Ddxof
Differential Diagnosis and Evaluation of Hyponatremia:
1) Identification of onset (acute vs. chronic)
2) Presence of symptoms (HA,
Differential Diagnosis ... renal disease), drug ... history #Diagnosis ... #EM #IM #Nephro ... #Algorithm #Ddxof
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Liver Enzymes - Differential ... Diagnosis Algorithm ... • Others #LFTs ... #Hepatology #LiverEnzymes ... Diagnosis #Algorithm
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Differential Diagnosis ... valproate, azoles), Drugs ... Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Causes of Hypocalcemia #Diagnosis #EM #IM #Endo #Hypocalcemia #Differential #Algorithm #PTH #Drugs #Ddxof
Hypocalcemia #Diagnosis ... #EM #IM #Endo # ... Hypocalcemia #Differential ... #Algorithm #PTH ... #Drugs #Ddxof
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Diagnosis Algorithm ... 15X ULN - Drugs ... Burak @kwburak #LFTs ... #diagnosis #hepatology