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hematology differential algorithm oncology classification folicacid hemolysis management aafp atlas bloodcell common cvid deficiency extravascular gap globulin hodgkins homocysteine hypogammaglobulinemia
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... Algorithm and Causes ... #Hemolytic #Anemia ... #Workup #Hematology ... #Diagnosis *
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... e.g. lupus, CLL, lymphoma ... antibiotics are the most frequently ... #hematology #anemia
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Vitamin B12 or Folate ... IgM associated lymphoma ... disease, Malignant lymphoma ... #differential #diagnosis ... #hematology #microscopy
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... • Leukemia • Lymphoma ... Antibody-mediated hemolysis ... Vitamin B12 • Folate ... #Hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... - Differential Diagnosis ... • Bleeding • Hemolysis ... Deficiency • Folate ... #Hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
Hemorrhage or hemolysis ... the most likely cause ... recovery also causes ... #Diagnosis #Macrocytosis ... #VitaminB12 #Folate
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
pregnant have hemolytic ... anemia, or psoriasis ... that can cause ... #differential #diagnosis ... #hematology #nutrition
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... available for rapid diagnosis ... result in severe anemia ... anemia Indirect ... #Workup #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... Workup: • Full ... #diagnosis #classification
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Metastatic cancer, Lymphoma
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