31 results
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease ... Pathophsiology ... storage disorder • Deficiency ... #Gauchers #Disease ... Diagnosis #Signs #Symptoms
Magnesium Deficiency and Alcoholism

Risks associated with Mg deficiency in alcoholism:
 • Affects protein synthesis. energy production,
Magnesium Deficiency ... atherosclerotic CVS disease ... • Depressive symptoms ... • Mg deficiency ... Alcoholism #alcohol #pathophysiology
Diagnostic Algorithm for Dizziness and Vertigo
Peripheral Vertigo:
 • Attacks: Sudden, severe, can last anywhere from seconds
Varies • No neurologic ... findings BPPV • Short-lived ... No auditory symptoms ... test Méniére's disease ... Long symptom-free
Risk Factors and Signs of Copper Deficiency
Risk Factors:
 • Gastrointestinal: Previous upper bowel resection/bariatric surgery, Inflammatory
Signs of Copper Deficiency ... Inflammatory bowel disease ... Chronic diarrhoea, Short ... drkeithsiau #Copper #Deficiency ... #riskfactors #symptoms
Causes of Peripheral and Central Vertigo
PERIPHERAL VERTIGO
1. Benign paroxysmal positional vertigo (BPPV) - Short-lived (typically less
vertigo (BPPV) - Short-lived ... Méniére's disease ... with significant neurologic ... course of the disease ... Disease onset usually
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... : • GH deficiency ... : - Short ... endocrinology #pathophysiology
Xeropthalmia: Pathogenesis and Ocular Manifestations

Decr Visual pigment -> Keratinization, thickening & non-wetting of the conjunctiva
with vitamin A deficiency ... conjunctiva) • Bitot's spots ... #Xeropthalmia #pathophysiology ... diagnosis #signs #symptoms
Central Retinal Artery Occlusion: Pathogenesis and clinical findings
 • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
• Inflammatory Disease ... , ATIII deficiency ... -> Cherry-red spot ... Occlusion #CRAO #pathophysiology ... diagnosis #signs #symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Pott's Disease in ... Clinical Signs/Symptoms ... decreased reflexes Pathophysiology ... Residency @CMC_IM #Potts ... #Disease #Tuberculosis
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
Sickle-cell disease ... Sickle cell disease ... The underlying pathophysiology ... co-existent G6PD deficiency ... Features #Signs #Symptoms