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diagnosis management pediatrics peds signs urinarytractinfection 21hydroxylasedeficiency 21ohd feedbackloop fungal gh growthhormone hematology hemeonc hemophagocytic hlh hyperparathyroidism hyperthyroidism infections infectiousdiseases
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Comparison: • Primary ... Phosphate Physical Symptoms ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings Note: Although rare, gestational diseases can lead to thyrotoxicosis due
Primary Hyperthyroidism ... Signs/Symptoms: ... Pretibial myxedema #Primary ... Hyperthyroidism #endocrinology ... #pathophysiology
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... fractures • Short ... PraderWilli #Syndrome #genetics ... #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... deficiency: - Short ... #FeedbackLoop #endocrinology ... #pathophysiology
Upper Urinary Tract infection (UUTI): Pathogenesis and Clinical Findings Predisposing Factors: - Immunocompromised, Diabetes, - Elderly, Female
Upper Urinary Tract ... Elderly, Female (short ... - Indwelling urinary ... UrinaryTractInfection #UUTI #Pathophysiology ... #Signs #Symptoms
Lower Urinary Tract Infection: Pathogenesis and Clinical Findings - Predisposing Factors: Immunocompromised state, diabetes, elderly, female
elderly, female (short ... epithelium and causing symptoms ... Signs/Symptoms ... UrinaryTractInfection #LUTI #Pathophysiology ... #Signs #Symptoms
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... #21HydroxylaseDeficiency #21OHD #pathophysiology ... #genetics #endocrinology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Rheumatologic symptoms ... gastrointestinal 4) Primary ... yeast • Found primarily ... Inhalation of spores ... Aspergillosis Pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Types of HLH • Primary ... Familial) HLH: - Genetic ... Common Signs and Symptoms ... Pathophysiology
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