9 results
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
algorithm for bone ... patients with monoclonal ... significance (MGUS) A bone ... whom there are no clinical ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... accumulation of clinical ... , Biological + Bone ... /ml, ↑ LDH • Bone ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... : Overwhelming clinical ... / Diagnosis: HLH ... Hemophagocytosis in bone ... management #treatment #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... fever syndromes Clinical ... Fever is the main clinical ... Diagnosis #Management #Hematology ... #Rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
common in Asia • HLA-B51 ... association • M > F Clinical ... Behcet syndrome (Clinical ... refractory disease : monoclonal ... signs #symptoms #rheumatology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... subtypes: - Nodular ... (LDHL) - Nodular ... anymore • Routine bone ... classification #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Complications of Monoclonal ... osteoclast activity and bone ... resorption - Bone ... rituximab (in clinical ... Complications #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... Clinical Presentation ... Pathophysiology ... Hemophagocytosis in bone ... Diagnosis #Management #Hematology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
plasmacytoma of bone ... • Occur in bone ... plasmacytoma) Clinical ... tissue composed of monoclonal ... Diagnosis #Workup #Hematology