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diagnosis management anemia myelodysplastic product reactions treatment algorithm apl apml auer calculation cancer chronic clinical cll differential index lymphocytic myelodysplasia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
• Bone marrow ... transformation to acute ... leukemia Management ... Management #treatment #hematology ... #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... with hypocellular bone ... Can progress to MDS ... or acute leukemia ... management #treatment #hematology
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
Acute promyelocytic ... leukemia (blood ... Kyle Bradley, MD ... #Auer #Rods #Acute ... APML #Pathology #Hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... virus (EBV) • Leukemia ... result from low blood ... #Anemia #oncology ... #hematology #diagnosis
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... the peripheral blood ... Blast cells - Blood ... CLL -> Invade Skin ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... Pure red cell aplasia ... Warm AIHA • Bone ... ’s lymphoma or acute ... #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
the peripheral blood ... marrow failure: Aplastic ... Index > 3: • Acute ... blood loss: Trauma ... Production #Index #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
just beneath the skin ... Causes • Anemia • Aplastic ... • Hairy Cell Leukemia ... Syndromes #diagnosis #hematology ... #oncology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
• Acute Hemolytic ... Transfusion Related Acute ... due to marrow aplasia ... infections with skin ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
- Acute Hemolytic ... due to marrow aplasia ... infections with skin ... by Nick Mark MD ... diagnosis #management #hematology
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