19 results
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... - Highest • Bone ... Most common symptoms ... symptoms - Pain ... Differential #Diagnosis #Algorithm
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
• softening of bones ... of feet, thigh bones ... : Inhibitor of bone ... collection with EDTA Pathophysiology ... mineralization Symptoms
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... rapid onset of symptoms ... chronic onset of symptoms ... Symptoms: • Malaise ... Leukemia #Hematology #Oncology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... suspicious clinical symptoms ... box indicates all ... ALP, alkaline phosphatase ... LFTs #Abnormal #Algorithm
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Clinical Signs/Symptoms ... back pain - Symptoms ... decreased reflexes Pathophysiology ... of bacilli to bone ... should be done in ALL
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
3: Necrosis of bone ... inner cortical bone ... #Mastoiditis #pathophysiology ... #signs #symptoms ... #diagnosis #otology
Fever of Unknown Origin (FUO) - Further Workup

 • CNS symptoms? Get an LP and imaging
Workup • CNS symptoms ... Get an LP and imaging ... Returning Traveler’ algorithm ... Bone marrow biopsy
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... lymphocyte predominant (LP ... pattern of spread, B symptoms ... Classification #pathophysiology ... #differential #algorithm
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... management #hematology #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
level <3 g/dL • Bone ... constitutional symptoms ... multiple myeloma, AL ... light-chain myeloma and AL ... hematology #diagnosis #oncology