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diagnosis signs clinical pocus management complications syndrome kidney msk differential disease hepatology liver orthopedics algorithm endocrinology hematology metastases metastatic transverse
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Phosphate Physical Symptoms ... signs, Fragile bones ... easily/weakness, Bone ... pain Psychiatric Symptoms ... Secondary #Tertiary #pathophysiology
Hypercalcemia of Malignancy - Pathophysiology PTH-mediated • Parathyroid cancer • Ectopic production: Small cell lung cancer, ovarian
of Malignancy - Pathophysiology ... D - Increased renal ... resorption in the bone ... resorption in the bone ... Cell of lung, Renal
Stress Fracture: Pathogenesis and clinical findings Abnormal biomechanics, Repetitive impact activities => Repetitive subthreshold mechanical loading => Bone strain =>
mechanical loading => Bone ... strain => Bone ... #orthopedics #pathophysiology ... #symptoms #signs
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• softening of bones ... collection with EDTA Pathophysiology ... mineralization Symptoms ... neuropathy • Renal ... : - Renal failure
Initial treatment of renal bone disease and cinacalcet for secondary hyperparathyroidism Phosphate binders reduce hyperphosphataemia and hyperparathyroidism.
Initial treatment of renal ... bone disease and ... which reduces bone ... #Pharmacology #Pathophysiology
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 Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... #Osteoporosis #pathophysiology ... #signs #symptoms
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Highest • Bone ... Most common symptoms ... Pregnancy - Renal ... disease - Bone ... symptoms - Pain
Colchicine Toxicity Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly] 2-24 hrs • Severe GI distress
2-7 days • Bone ... Rhabdomyolysis • Renal ... Toxicity #Toxicology #Symptoms
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease Pathophsiology ... Osteonecrosis, bone ... Diagnosis #Signs #Symptoms
Horseshoe Kidney on Transverse Abdominal POCUS Dr. Robert Jones @RJonesSonoEM #Horseshoe #Kidney #Transverse #Abdominal #POCUS #Renal #Ultrasound #Clinical
Robert Jones @RJonesSonoEM ... Abdominal #POCUS #Renal ... #Ultrasound #Clinical
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