7 results
Ossification of Carpal Bones

It’s always tricky to remember the age of ossification of the carpal bones
Ossification of Carpal ... ossification of the carpal ... interpreting a Pediatric ... -6-7 years for Triquetral ... Diagnosis #Peds #Pediatrics
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... Incr IGF1 • Bone ... lipolysis Signs/Symptoms ... expansion (e.g. carpal ... endocrinology #pathophysiology
Age of Ossification of Carpal Bones
Capitate - 1 Month
Hamate - 2 Months
Triquetral - 3 Years
Lunate -
Ossification of Carpal ... Bones Capitate ... Hamate - 2 Months Triquetral ... bones! ... diagnosis #msk #pediatrics
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... GH excess prior ... overgrowth: • Carpal ... diagnosis #signs #symptoms ... endocrinology #pathophysiology
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Syndrome Signs/Symptoms ... Infertility • Decr Bone ... Syndrome #genetics #pathophysiology ... #peds #pediatrics
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
in subchondral bone ... boggy" joints, esp carpal ... and subcondral bone ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
cause excessive bone ... turnover -> Incr bone ... the vertebral canal ... PagetsDisease #pathophysiology ... diagnosis #signs #symptoms