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clinical pocus diagnosis hepatic ruq abdominal differential hepatology management pathophysiology signs disease metastases metastatic trauma workup algorithm alkaline alp artery
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Boxes in yellow ... suspicious clinical symptoms ... shown in the grey boxes ... Green boxes indicate ... mellitus; USS, ultrasound
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... - Highest • Bone ... • Liver (80%) ... Most common symptoms ... symptoms - Pain
Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... IBD • Chronic liver ... pathophysiology #signs #symptoms
Clinical manifestations of acute liver failure Brain: Hepatic encephalopathy, Cerebral edema, Intracranial hypertension,
manifestations of acute liver ... abnormalities Liver ... Hepatopulmonary syndrome Bone ... manifestations #acute #liver ... failure #Signs #Symptoms
Syphilitic gummas in Tertiary syphilis Tertiary syphilitic gummas may mimic basal cell carcinoma. The gummatous tumors are
are no signs or symptoms ... blood vessels, liver ... , bones, and joints
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... postpartum): • Initial symptoms ... malaise) → Acute liver ... Antithrombin Ill • Ultrasound
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
synthesized in: liver ... , bone, placenta ... • softening of bones ... of feet, thigh bones ... mineralization Symptoms
Fever of Unknown Origin (FUO) - Further Workup • CNS symptoms? Get an LP and imaging
Workup • CNS symptoms ... duplex or CTA • Liver ... Liver biopsy • ... Bone marrow biopsy
Interstitial keratitis in Tertiary Syphilis Interstitial keratitis, which is an inflammation of the cornea’s connective tissue elements,
are no signs or symptoms ... blood vessels, liver ... , bones, and joints
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone: • Liver ... Incr IGF1 • Bone ... lipolysis Signs/Symptoms
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