36 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Causes of Extravascular ... and Intravascular ... circulation - Infections ... • Malaria ... Diagnosis #Algorithm #Causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... Mycoplasma pneumoniae infection ... spherocytosis) • Infections ... : Malaria, Babesiosis ... #Causes #differential
#protozoa #toxoplasma #leishmania #trypanosoma #babesia #malaria #plasmodium #cryptosporidium #cyclospora #cystisospora #entamoeba #acanthamoeba #microsporidia

#ID  #InfectiousDiseases
toxoplasma #leishmania #trypanosoma ... #babesia #malaria ... InfectiousDiseases #Infections
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Anemia Intrinsic Causes ... drug induced • Infections ... Bartonella, Babesia, Malaria ... IVIG infusion Intravascular ... Causes: • MAHA
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis Algorithm
Neoplasm:
• NHL
• Hodgkin's lymphoma
• Leukemia
• Solid
Causes of Fever ... • Trauma Non-infectious ... • Infectious ... Protozoa (eg. malaria ... Diagnosis #Algorithm #causes
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
bacteremia • Malaria ... endocarditis, malaria ... • Pyemia Malarial ... or no fever • Malaria ... Causes: • Still's
Faget Sign - Pulse-Temperature Dissociation
Causes of Relative Bradycardia
 • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Dissociation Causes ... Bradycardia • Infectious ... Causes: Legionella ... Typhus, Babesiosis, Malaria ... fever • Non-Infectious
Faget's Sign & Liebermeister's Rule
Pulse-Temperature Dissociation
EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM
INFECTIOUS
INCREASES 8-10 BPM INFECTIOUS ... CAUSES • Legionella ... Babesiosis • Malaria ... • Fever OTHER CAUSES ... the most likely infection
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Triggering factor (infection ... Leishmaniosis, malaria ... lymphoma (DLBCL, intravascular ... Still disease, Infection ... Drugs, Unknown cause
Causes of Secondary IgA Nephropathy - Differential Diagnosis Algorithm
 • GI disorders: Celiac disease, Crohn's disease,
Causes of Secondary ... Hep B and C • Infections ... Chronic mucosal infections ... , Malaria, Schistosomiasis ... #Nephropathy #Causes