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Causes of acute kidney injury (AKI). AKI is classified into pre-renal, renal, and post-renal causes. Renal
kidney injury (AKI ... AKI is classified ... into pre-renal, ... renal, and post-renal ... supply; glomerular, tubular
Causes of Acute Kidney Injury - Differential Diagnosis Framework 
Pre-Renal
Post-Renal
Intrinsic Renal:
 • Tubules (ATN)
 • Glomerular:
Framework Pre-Renal ... Post-Renal Intrinsic ... Renal: • Tubules ... drtonydang @CMC_IM #AKI
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Kidney Injury (AKI ... Framework PRE-Renal ... Shunting INTRA-Renal ... , Anti-GBM • Tubular ... Drug-induced POST-Renal
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
Creatinine: • AKI ... Medications that ↓ renal ... tubular secretion ... Cystatin C: • AKI ... Biomarkers #Kidney #renal
Kidney Syndromes - A Guide to Compartmentalize the Etiologies of Kidney Disease
1) Tubule and interstitium
2) Vasculature
3)
Kidney Disease 1) Tubule ... galindozip #Renal ... Failure #Injury #AKI
General approach to AKI - Checklist

Urine electrolytes & FENa - Previously, it was believed that urine
General approach to AKI ... differentiate between pre-renal ... and intrinsic renal ... diagnosing acute tubular ... @PulmCrit #AKI
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Kidney Injury (AKI ... at least 50% Renal ... Shock Acute Tubular ... • Pigments Tubular ... Sjögren) Post-Renal
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal

PRE-RENAL 
Impaired perfusion: 
•
Kidney Injury ( AKI ... ) - Prerenal, Renal ... Postrenal PRE-RENAL ... vasculitis Acute tubular ... Infection POST-RENAL
Acute Kidney Injury - Differential Diagnosis Framework
PRERENAL:
 - Intrarenal vasoconstriction-hemodynamically mediated
 - Systemic vasodilation
 - Volume
casts on UA) - Tubular ... (renal tubular ... - Diaqnosis: Renal ... - Diagnosis: Renal ... Kidney #Injury #AKI
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Kidney Injury (AKI ... gammopathy of renal ... syndrome • Proximal tubular ... bevacizumab (VEGFi), TKi ... Kidney #Injury #AKI