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diagnosis differential causes emergencies oncologic cancer generalized hemeonc infections lysis management mycobacteria myelitis neuromuscular nontuberculous ntm syndrome transverse
Tumor Lysis Syndrome (TLS) Pathophysiology Culprits: ALL, Burkitt, SCLC Cells all die at once = ↑Phos, ↓Ca, ↑K,
Tumor Lysis Syndrome ... (TLS) Pathophysiology ... worsens above #Tumor ... #Pathophysiology ... #oncology
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness ... : UMN (stroke, tumor ... Polyneuropathy, ALS ... #Generalized #Weakness ... Diagnosis #causes #neurology
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Myelitis, Trauma, Tumor ... Motor Nerves: ALS ... Neuromuscular #Weakness ... differential #diagnosis #neurology
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Oncologic Emergencies ... of breath • Neurologic ... EMERGENCIES: Tumor ... mental function • Weakness ... Constipation • Muscle weakness
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... disorder (Cardiac, pulmonary ... system: Brain tumor ... aminotransferases • Serology ... Differential #Diagnosis #neurology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
antibiotics TLS ... (tumor-lysis syndrome ... low Ca - q8 h TLS ... Lower-extremity weakness ... renal failure, pulmonary
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
rapid onset of weakness ... monophasic Pathophysiology ... Weakness: - Weakness ... Enhancement - TM and tumor ... diagnosis #management #neurology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Illnesses: • Pulmonary ... complicate MAC pulmonary ... including therapy with tumor ... • Malaise, • Weakness ... differential #diagnosis #infectiousdiseases
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