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Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
Nephritic vs Nephrotic ... /nephritic syndromes ... hematuria (RBC casts ... #Syndrome #Comparison ... #Diagnosis
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
and Nephrotic Syndromes ... Nephritic syndrome—due ... RBC casts in urine ... but in severe cases ... #Nephrotic #Syndromes
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
Syndrome and Nephritic ... Syndrome == Nephrotic ... Red blood cell casts ... Red blood cell casts ... #Nephrology #Diagnosis
Acute Kidney Injury (AKI) - Common Patterns on Urinalysis
 - Prerenal
 - ATN
 - AIN
 -
Acute Kidney Injury ... AIN - UTI - Nephrotic ... Syndrome - Nephritic ... #Urinalysis #diagnosis ... #table #comparison
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
Interstitial Nephritis ... sensitive) • AKI ... sterile pyuria, WBC casts ... proteinuria, granular casts ... #Interstitial #Nephritis
Urinary Casts and Disease Associations
Hyaline - May be nonspecific; seen in normal individuals or during severe
Urinary Casts and ... breakdown of cellular casts ... heme-granular casts ... tubulointerstitial nephritis ... tuberculosis Fatty - Nephrotic
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm
Acute Kidney Injury (AKI) - Acute increase
Causes of Acute ... - Differential Diagnosis ... • Hepatorenal syndromes ... Epithelial cell casts ... Interstitial Nephritis
Causes of Generalized Edema - Differential Diagnosis Algorithm
Overfill (Increased renal sodium retention, Urine Na > 40meq/L)
Causes of Generalized ... • NSAlDs • AKI ... /CKD • Nephrotic ... Oncotic Pressure • Nephrotic ... • Sepsis • Acute
Urine Microscopy - Casts
Acellular Casts
 • Hyaline Casts - Consists of only precipitated Tamm-Horsfell protein without
suggestive of acute ... in a variety of acute ... suggestive of nephrotic ... sydnrome • Pigment ... interpretation #diagnosis
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
a.k.a. cardiorenal syndrome ... tubular necrosis (causes ... nephritis (AIN) ... Classification #diagnosis ... #nephrology