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Algorithm for the Evaluation and Management of Transfusion Reactions

This algorithm was developed by Dr. Eric Madden,
of Transfusion ... Reactions This ... #Transfusion #Reactions ... #Algorithm #Diagnosis ... #Management #Hematology
Transfusion Reactions - Summary Cheatsheet
 • Hemolytic Reaction
 • Febrile Reactions
 • Transfusion Related Acute Lung
Transfusion Reactions ... • Febrile Reactions ... Graft Vs Host Disease ... #Reactions #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Graft Versus Host Disease ... infections with skin ... Borrellia (Lyme disease ... #diagnosis #management ... #hematology #reactions
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Graft Versus Host Disease ... infections with skin ... Borrellia (Lyme disease ... #diagnosis #management ... #hematology #reactions
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... HUS) • Other: Transfusion ... reaction, Paroxysmal ... reaction • Intrinsic ... #hematology #anemia
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... AIHA, Cold AIHA, Transfusion ... reactions, Drug-associated ... , Drugs, Liver Disease ... #hematology
Differential Diagnosis for Hemolytic Anemia
Intrinsic Causes:
 • Enzyme deficiencies ex. G6PD, pyruvate kinase 
 • Hemoglobinopathies
Differential Diagnosis ... Causes: • Liver disease ... prosthetic valve • Transfusion ... reactions ex. ... classification #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... fever • Drug reactions ... #Differential #Diagnosis ... #hematology #rheumatology
Erythematous Rashes - THE ALGORITHMIC APPROACH

Characterized by diffuse redness of the skin due to
capillary congestion, erythematous
redness of the skin ... includes Kawasaki disease ... an anaphylactic reaction ... or an exposure reaction ... #Diagnosis #Dermatology
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... Arthralgia/arthritis, Skin ... Differential Diaqnoses ... #diagnosis #management ... #treatment #rheumatology