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management oncology differential rheumatology treatment algorithm hemeonc hemophagocytic hlh infections infectiousdiseases leukemia lymphohistiocytosis pathophysiology ra abnormal acquired agglutinin aids aplastic
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Differential Diagnosis ... Hepatopulmonary syndrome ... of Dyspnea: • Chest ... Transverse myelitis • Hematology ... : - Anemia •
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Purpura, Urticaria Chest ... ) Blood (75%): Anemia ... erythematosus #signs ... #symptoms #diagnosis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... , dyspnea, +/- CXR ... WBC >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
reticularis Blood: Anemia ... pleural effusion on CXR ... interstitial lung disease/pulmonary ... pathophysiology #signs ... #symptoms #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Clinical Presentation ... • Improve the symptoms ... #oncology #hematology ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... common • Imaging: CXR ... - pulmonary opacities ... >3 symptoms, or> ... #management #hematology
Refeeding Syndrome: Pathogenesis and clinical findings Patients at Risk of Refeeding Syndrome: - Little or no nutritional
Pathogenesis and clinical ... - CHF - Pulmonary ... hemolysis - anemia ... #diagnosis #pathophysiology ... #symptoms #signs
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... of anemia include ... anemia • Cold ... #hematology #diagnosis
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
renal failure Clinical ... e.g. incidental CXR ... Pulmonary: dyspnea ... , cough, chest pain ... #Management #Signs
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
ARDS to explain symptoms ... fluid balance, and CXR ... with pulmonary ... Transfusion #Reactions #hematology ... #diagnosis #comparison
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