38 results
CREST Syndrome: Pathogenesis and Clinical Findings

CALCINOSIS (BB-sized, hard nodules in fingers)
RAYNAUD'S Phenomenon
ESOPHAGEAL DYSMOTILITY
SCLERODACTYLY (thickening and tightening
CREST Syndrome: ... tightening of skin ... TELANGIECTASIA (In face, hands ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
Clinical: • Disease ... exertion • Neurologic ... neuropathies • Skin ... #Sarcoidosis #Diagnosis ... #Symptoms #Signs
Clinical Manifestations of Serotonin Syndrome
 • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements)
 • Gastrointestinal: Diarrhea,
Ophthalmologic ... Cardiovascular and ... Hyperthermia UCSD ... #Symptoms #spectrum ... #signs #diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
response to local skin ... injury) • Neurologic ... meningitis), MCC CNS symptoms ... inhibitors • Uveitis- Ophthalmology ... #signs #symptoms
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings
• Primary Sjögren's is a solitary process whereas secondary Sjögren's
: Pathogenesis and ... / Symptoms: - ... Xeroderma (Dry skin ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... variably: On one hand ... required due to skip ... required +/- prompt ophthalmology ... #Symptoms #Diagnosis
Cushing's Syndrome - Moon Facies, Buffalo Hump, Abdominal Striae, Thin Skin

A young man presents with rapid
Cushing's Syndrome ... Abdominal Striae, Thin Skin ... the patient's hand ... Next diagnostic ... #Signs #MoonFacies
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Anterior Cord Syndrome ... clumsiness in hands ... #diagnosis #pathophysiology ... #signs #symptoms ... #orthopedics #neurology
What is a Boxer’s fracture?? Fracture of the 4th or 5th metacarpal neck
 - Common in
falls onto the hand ... Symptoms/exam ... aspect of the hand ... Always check for skin ... – compartment syndrome
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
- Differential Diagnosis ... Presentation: Systemic Symptoms ... purpura: Strong sign ... , neurologic, and ... • Progressive symptoms