12 results
diagnosis clinical management pathophysiology rheumatology differential endocrinology growthhormone arteritis autoimmune behcet boxers buffalohump crest cushings dermatology disease excess feedbackloop fingernails
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates osteoblasts and ... activates lipolysis Signs ... /Symptoms: • GH ... acromegaly, widening of hands ... tunnel, OSA, Incr skin
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
GH excess prior ... Carpal Tunnel Syndrome ... • Enlarged hands ... Overproduction #diagnosis #signs ... #symptoms #endocrinology
CREST Syndrome: Pathogenesis and Clinical Findings CALCINOSIS (BB-sized, hard nodules in fingers) RAYNAUD'S Phenomenon ESOPHAGEAL DYSMOTILITY SCLERODACTYLY (thickening and tightening
CREST Syndrome: ... tightening of skin ... TELANGIECTASIA (In face, hands ... Pathophysiology #Diagnosis #Signs ... #Symptoms
Clinical Manifestations of Serotonin Syndrome • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements) • Gastrointestinal: Diarrhea,
• Ophthalmologic ... Cardiovascular and ... Hyperthermia UCSD ... #Symptoms #spectrum ... #signs #diagnosis
What is a Boxer’s fracture?? Fracture of the 4th or 5th metacarpal neck - Common in
Symptoms/exam ... aspect of the hand ... Always check for skin ... – compartment syndrome ... Overlying wounds or signs
Cushing's Syndrome - Moon Facies, Buffalo Hump, Abdominal Striae, Thin Skin A young man presents with rapid
Cushing's Syndrome ... Abdominal Striae, Thin Skin ... gain (license photo ... the patient's hand ... #Signs #MoonFacies
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
response to local skin ... meningitis), MCC CNS symptoms ... inhibitors • Uveitis- Ophthalmology ... diagnosis #management #signs ... #symptoms #rheumatology
Secondary Syphilis Rash Secondary syphilis is the most contagious of all the stages of this disease, and
this disease, and ... Skin rash and malaise ... The signs and symptoms ... the palms of the hands ... Diagnosis #Clinical #Photo
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... • Progressive symptoms ... occasional oligoclonal bands ... vasculitis • Cogan syndrome
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... variably: On one hand ... required due to skip ... required +/- prompt ophthalmology ... GCA #Temporal #Signs
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