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Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... specific for the liver ... Value = (ALT / ULN ... SinaiBmoreIMRes #Liver ... Transaminitis #diagnosis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... value = (ALT + ULN ... phosphatase + ULN ... Transaminitis #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential Diagnosis ... Severe ALT > 15x ULN ... Mild ALT < 5x ULN ... #Differential #Diagnosis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... - Differential Diagnosis ... Severe - ALT >15X ULN ... Mild - ALT < 5x ULN ... Transaminitis #Algorithm #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... Identify Acute Liver ... #chemistry #diagnosis
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
disease to acute liver ... hepatocellular pattern of liver ... , AIH diagnosis ... ALT + AST > 5x ULN ... AND IgG > 2x ULN
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... AST/ALT (5-10x ULN ... ) Differential Diagnosis ... obstetrics #obgyn #diagnosis
HAS-BLED Score - Risk of Major Bleeding in 1 Year Characteristics (1 point each) • Hypertension: Baseline
transplant • Liver ... bilirubin > 2x ULN ... /Alk phos > 3x ULN ... anticoagulation #diagnosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
cholestasis → Cirrhosis/Liver ... • ALP > 1.5 x ULN ... or higher • Liver ... Differential Diagnosis ... #cholangitis #diagnosis
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
severe HTN • Diagnosed ... • First diagnosed ... pits <100k), ↑ liver ... enzymes (2x ULN ... hemolysis, elevated liver
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