897 results
Hypertensive Disorders of Pregnancy
Chronic Hypertension:
 • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg
 •
• First diagnosed ... pits <100k), ↑ liver ... enzymes (2x ULN ... doubling of Cr), pulmonary ... hemolysis, elevated liver
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... Value = (ALT / ULN ... SinaiBmoreIMRes #Liver ... Transaminitis #diagnosis
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... value = (ALT + ULN ... phosphatase + ULN ... Transaminitis #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... - Differential Diagnosis ... Severe ALT > 15x ULN ... Mild ALT < 5x ULN ... #Differential #Diagnosis
Diagnostic algorithm for a child or adolescent with suspected pulmonary hypertension. CHD, congenital heart disease; CPET,
Diagnostic algorithm ... with suspected pulmonary ... thromboembolic pulmonary ... disease; LFT, liver ... #Diagnosis #Peds
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... - Differential Diagnosis ... Severe - ALT >15X ULN ... Mild - ALT < 5x ULN ... Transaminitis #Algorithm #diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... R-value: Serum (ALT/ULN ... ALT) / (Alk phos/ULN ... Identify Acute Liver ... #chemistry #diagnosis
Hepatopulmonary Syndrome (HPS) 

HPS-differential diagnosis:
1. Pulmonary vasculature
2. Diseases of the lung parenchyma
3. Pleura and diaphragm

HPS-diagnosis:
1. Patients
HPS-differential diagnosis ... Pulmonary vasculature ... Patients with liver ... HPS #hepatology #pulmonary ... #diagnosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... AST/ALT (5-10x ULN ... ) Differential Diagnosis ... obstetrics #obgyn #diagnosis
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
disease to acute liver ... hepatocellular pattern of liver ... , AIH diagnosis ... ALT + AST > 5x ULN ... AND IgG > 2x ULN