263 results
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Liver Enzymes (LFTs ... and Cholestatic Liver ... Hepatocellular Liver ... or Cholestatic Liver ... @AnnKumfer #Liver
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... kidney, brain ALT ... specific for the liver ... / ULN ALT) / (ALP ... SinaiBmoreIMRes #Liver
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Severe ALT > 15x ... ULN • Viral ... Differential #Diagnosis #Algorithm
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... : • Severe - ALT ... >15X ULN ... Transaminitis #Algorithm
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... /ULN ALT) / (Alk ... Identify Acute Liver ... than ALTALT ... : Specific to liver
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
Focus on prior Liver ... Vitals - LFTs, plt ... biopsy Meds: ... - Outpatient meds ... prior hepatotoxic meds
HAS-BLED Score
 - Hypertension: Baseline SBP > 160mmHg
 - Renal disease: Cr > 2.6mg/dL, on HD,
transplant - Liver ... bilirubin > 2x ULN ... , or AST/ALT/alkphos ... > 3x ULN - History ... of antiplatelet meds
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... Findings: • ↑AST/ALT ... (5-10x ULN), ↑Tbili ... Cr, ↓Glucose, ↓PLT
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... than ALTALT ... • AST: ↑ • ALT ... - ALP > AST/ALT ... differential #diagnosis #algorithm
HAS-BLED Score - Risk of Major Bleeding in 1 Year
Characteristics (1 point each)
 • Hypertension: Baseline
transplant • Liver ... bilirubin > 2x ULN ... , or AST/ALT/Alk ... phos > 3x ULN ... Of antiplatelet meds