7626 results
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
involving both UMN ... respiratory failure Diagnosis ... Medical time to diagnosis ... Other possible diagnosis ... in differential diagnosis
Incomplete spinal cord syndromes (ISCS)
 • Central - Small Lesion - Suspended sensory deficit, classic cape
Disproportionate motor (UMN ... Ipsilateral weakness (UMN ... paraparesis (mixed UMN ... and LMN types) ... spinalcord #syndromes #diagnosis
Upper Motor Neuron (UMN) lesions are lesions occurring anywhere in the CNS from the brain up
Motor Neuron (UMN ... the differential diagnosis ... However, in UMN ... UMN lesions are ... @DharSaty #UMN
Bilateral LMN palsy with tongue weakness, wasting and fasciculations.  →  Bulbar motor Neuron disease

Note
Bilateral LMN palsy ... differentiates this from an UMN ... fasciculations #LMN
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
- Differential Diagnosis ... Infection • Neuro: UMN ... stroke, tumor), LMN ... #Differential #Diagnosis
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Phosphatase, ALT ≥ 3x ULN ... Transaminase, ALP ≥ 2x ULN ... Value = (ALT / ULN ... ALT) / (ALP / ULN ... Transaminitis #diagnosis
Spontaneous Bacterial Peritonitis
DIAGNOSTICS
Paracentesis: 
 • Calculate absolute PMN count (total WBC x PMN %)
 • Correct
Bacterial Peritonitis DIAGNOSTICS ... Calculate absolute PMN ... %) • Correct PMN ... RBCs (subtract 1 PMN ... Peritonitis #SBP #diagnosis
Peritonitis - Spontaneous vs Secondary vs Peritoneal Dialysis Associated Peritonitis
Spontaneous Bacterial Peritonitis
 • Cirrhosis (high SAAG)
) + ascites w/ PMN ... glucose < 50, LDH ULN ... Secondary #Peritoneal #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
- Differential Diagnosis ... Severe ALT > 15x ULN ... Moderate ALT 5-15x ULN ... Mild ALT < 5x ULN ... #Differential #Diagnosis
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
CK: Up to 50X ULN ... CK: Up to 50X ULN ... Associated Features: Diagnosis ... over years, often diagnosed ... #differential #diagnosis