15 results
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
overgrowth: • Carpal ... Cardiovascular disease ... Overproduction #diagnosis ... #signs #symptoms ... #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... /Symptoms: • GH ... expansion (e.g. carpal ... #FeedbackLoop #endocrinology ... #pathophysiology
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
paresthesias (carpal ... malignancy Pathophysiology ... Differential Diagnosis ... #Management #Endocrinology ... #Treatment #Pathophysiology
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
Pathogenesis and Joint diseases ... boggy" joints, esp carpal ... Boutonniere's ulnar ... #signs #symptoms ... #diagnosis
Common Hand Fractures on X-Ray
Mallet finger - injury to the lateral extensor slips
Boutonniere deformity - injury
thumb injury to ulnar ... Terry thomas sign ... Kienboch disease ... #differential # ... diagnosis
Graves’ Disease: Pathogenesis and Clinical Findings
B & T lymphocyte mediated autoimmunity attack TSH receptor -> Continuous
Graves’ Disease: ... GravesDisease #pathophysiology ... #endocin #endocrinology ... #symptoms #signs ... #diagnosis
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
sensory • Before diagnosis ... intervertebral disc disease ... MeralgiaParesthetica #MSK #pathophysiology ... #differential # ... diagnosis #signs
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... failure PBC Signs ... and Symptoms: ... bile ducts Differential ... Diagnosis: •
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
goiter (Graves' disease ... TRAb) if Graves' disease ... #differential # ... endocrinology #signs ... #symptoms #thyroid
Scoliosis: Pathogenesis and clinical findings (Cobb Angle > 10 Degrees)

 • Incr Axial rotation of thoracic
intervertebral canal ... Restrictive Pulmonary Disease ... #Scoliosis #pathophysiology ... #msk #diagnosis ... #signs #symptoms